"A team from the University of Otago discovered a new way bacteriophages disable bacterial defenses, revealing a protein that binds both DNA and RNA. This finding could pave the way for phage-based alternatives to antibiotics and advances in gene regulation." (ScitechDaily, Hidden Arsenal Exposed: Surprise Discovery Has Big Antibacterial Potential)
The bacteriophages are viruses that destroy bacteria. Those viruses can transformed into nanomachines by destroying their DNA. There is a protein and the nano spring inside the tube, and when that machine is at the right point, the nano spring opens and sends the harpoon to the targeted bacteria.
In that case, the bacteriophage's DNA is replaced using the nano-harpoon, that destroys the targeted cells. Another thing is that those bacteriophages' shape allows researchers to create nanotechnical cranes and nano drills that can create nanobubbles or move some other cells.
The dead bacteriophage can act as medicine. The dead virus, in which DNA is removed can be driven into the wanted cell's ion pump. There the ion pump pulls that virus's legs open, and then that thing can keep the ion pump open. In some other cases, the virus body travels in the cell, and then the ion pump makes it rotate. That thing can form microbubbles in the cells.
The system that makes viruses travel to the right bacteria is also interesting. That thing can connected with the new medicines. If there are some kind of proteins or enzymes, that allow bacteriophages to find bacteria, that thing can used to make medicines that travel into wanted cells. And then those medicals activate in that target cell. That saves the body from the side effects.
The bacteriophage protein that it uses to cheat bacteria can have medical use. In those scenarios, medicine is closed in that protein shell, and then it will transfer to the body. The medicine that will not activate bacteria's chemical defense will be the next-generation tool.
The protein allows to use of lower doses of the medicine, which makes those medicines safer. This protein is also able to be used in genome transfer. The protein will help the wanted genome to find the targeted cells.
In that case, the bacteria will get the genome, which turns it to create peptides that fill the targeted bacteria. The idea is to use the bacteria's ability to exchange genomes against bacteria itself. When another bacteria comes, the genetically engineered bacteria will transport peptide molecules in its fellow species. The peptide can be too long, and that terminates targeted bacteria.
Those peptides can kill bacteria immediately by cutting their protein shell. The other version is to use a system that transports those peptides or polymeric molecules into the targeted cells. Then magnetic or acoustic system puts those molecules spin. That forms microbubbles that can fill the bacteria.
Another thing that makes bacteriophages interesting is their ability to find the right bacteria. If that ability can connected to medicals, that thing makes those medicals operate more accurately.
In the most interesting and futuristic models, those bacteriophages can transport nano-phonons to the targeted points. Then the laser light or some other oscillation will be targeted to the the wanted point. And then those phonons point the monotonic sound to that target. This system can remove plaque from the blood vessels, and destroy viruses and cancer cells.
https://scitechdaily.com/hidden-arsenal-exposed-surprise-discovery-has-big-antibacterial-potential/
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